Pancreatic stellate cells (PSCs) are the principal source of fibrosis in the stroma and interact
closely with cancer cells to create a tumor facilitatory environment that stimulates local tumor
growth and distant metastasis. Pancreatic fibrosis is initiated when PSCs become activated and
undergo morphological and, more importantly, functional changes so that the rate of extracellular
matrix (ECM) deposition exceeds the rate of ECM degradation in the gland. It is now well established
that pancreatic cancer cells activate PSCs leading to increased fibrosis.
Phillips P. Pancreatic stellate cells and fibrosis. In: Grippo PJ, Munshi HG, editors. Pancreatic Cancer and Tumor Microenvironment. Trivandrum (India): Transworld Research Network; 2012. Chapter 3. Available from: https://www.ncbi.nlm.nih.gov/books/NBK98937/
Also Avaliable as:
T25 plated cells $550.00 shipped at room temperature. Cat# 36115-46-T25
T75 plated cells $750.00 shipped at room temperature. Cat# 36115-46-T75
120 Population doublings or up to 12 passages.
One million viable cells upon thawing of frozen cells, frozen vial of cells shipped in dry-ice.
This product would require pre-coated flasks with Human Pancreatic Cancer Stem Cell Extra-cellular Matrix Cat# E36115-46-T25 or T75, T150,T225 or Multi-well plates please inquiry
and Human Pancreatic Stellate primary Cell culture Complete Growth Media with Serum Cat# M36115-45S or serum free Media M36115-46 [which requires one to wean the cells off the serum]
Cell Cultures from single donors, 1000 different cell cultures available, please indicate which lots you require from the 1000 donors, or any subcategories of the cancer type at the time of order. If you do not specify the subcategory, we will provide you the Human Pancreatic Stellate Cell Culture,
randomly from our inventory.
Source: Human Pancreatic Cancer tissue
Positive Markers: Desmin.alpha actin, Vitamin A, GFAP, Periostin, Collagen 1
For non-academic use, please inquire for pricing.
Cells are only guaranteed with purchase of Celprogen Media and Celprogen Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.
1000 individual donors are fully characterized proprietary patient-derived xenografts (PDX) representing all major histotypes and capturing tumor diversity.
Subcutaneous, orthotopic and disseminated models. Extensive molecular and pharmacological characterization as well as information on patients' pretreatment to help you select the most appropriate model.
Integrated approach: use the same PDX models and/or the corresponding cell line in 2D/3D screening assays and follow-up in vivo studies, identify biomarkers predicting tumor sensitivity for your compound.
Individually tailored study designs: proof of concept, dose level and schedule optimization, combinations, biomarker identification, etc.