To Provide Toxicity Studies in Human Liver Organ System
Human Liver organ culture is generating in a 6 well format with media interface. The compounds of interest are introduced to the Human Liver organ matrix or in the media. Depending on the number of concentrations different well formats are utilized for the Study, 12, 24, 48 and 96 well formats. The following parameters can be evaluated from this organ culture system: IC50, Wnt pathway, SHH pathway, Notch pathway, TGFb pathway, proliferation rate, safety studies, and inhibition rates. Gene expression and protein profile studies for the compound of interest. Please inquire for specific biomarkers and proteins of interest.