Novel 3D Primary Human Cardiomyocyte Culture System for Evaluation of Candidate Drug Related Cardiac Safety Profile
Drug discovery and development are hampered by high attrition rates that are largely attributed to the reliance on model systems that are minimally representative of the underlying human biology. Although the animal models are a good overall proof of concept, safety and efficacy evaluations in such models are hard to extrapolate to the human situation. Thus, there is an urgent need for high-throughput human in-vitro cell based assay systems to predict safety profile of drugs for cardiac related ailments prior to clinical evaluation. Such human in vitro culture systems can be utilized in mechanism-based assays for cardiotoxicity assessment. It is becoming increasingly apparent that human primary cardiomyocytes can serve as the biological and physiological relevant in-vitro model system for drug discovery/ cardiotoxicity screens. In this study we screened 10 potential newly synthesized small molecules:CEP2001,2002,2003,2004,2005,2006,2007,2008,2009 and 2010.
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